Data analysis in single cell genomics

Partners involved: Stegle*, Theis*, Mukherjee, Ohler

The emergence of large single cell data sets, which are collected in international efforts such as the Human Cell Atlas (HCA), allow the modelling of molecular variation in a completely new resolution [28]. Theis and Stegle are members of the HCA consortium. Central challenges include

i) processing, homogenization and integration of huge amounts of data,

ii) tissue-spanning identification of cell types, iii) mapping of regulatory networks with single cell resolution.